Patent · US Active

Covalently linked polypeptide toxin-antibody conjugates

US10519249B2 · kind B2 · utility

2Cited by

86References

8Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Ulrich Brinkmann · Weilheim, DE
Eike Hoffmann · Viernheim, DE
Stefan Dengl · Munich, DE
Klaus Mayer · Prien am Chiemsee, DE

Key dates

Filing date	Jul 1, 2016
Grant date	Dec 31, 2019
Priority date	—
Expiry date	Jul 1, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/94
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Herein is reported a conjugate of a haptenylated polypeptide toxin and an anti-hapten antibody, wherein a disulfide bond is formed between a cysteine residue either before or after the lysine residue that is used for hapten-conjugation and a cysteine residue in the CDR2 of the antibody, whereby the CDR2 is determined according to Kabat.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.