Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
US10532108B2 · kind B2 · utility
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29Claims
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Key dates
| Filing date | Feb 8, 2019 |
| Grant date | Jan 14, 2020 |
| Priority date | — |
| Expiry date | Feb 8, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.