Methods of preparing inhibitors of influenza viruses replication

US10533004B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Luc Farmer · Foxborough, US
• Michael Boyd · Winchester, US
• David B. Miller, JR. · Waltham, US
• Valerie Ann Cwynar · Dracut, US

Key dates

• Filing date: Nov 9, 2017
• Grant date: Jan 14, 2020
• Expiry date: Nov 9, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method of preparing a compound of Formula (I) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (1): or a pharmaceutically acceptable salt thereof with Compound (2): in the presence of water, an organic solvent, a base, and a transition metal catalyst to generate a compound of Formula (I) or a pharmaceutically acceptable salt thereof.