Process for the preparation of xylene linked cyclam compounds

US10544109B2 · kind B2 · utility

Assignee

• Fresenius Kabi Oncology Ltd. · IN

Inventors

• Hemant Kumar Singh · Lucknow, IN
• Sandeep Kumar · Spring, US
• Ghanashyam Madhukar Sonavane · Barwala, IN
• Vishal Handa · Barwala, IN
• Chandan Gupta · Dhamtari, IN
• Sunil Sanghani · Manesar, IN
• Potru Sivaiah · Barwala, IN
• Saswata Lahiri · Sindhar, IN
• Walter Cabri · Sant Celoni, ES
• Nitin Gupta · Savanuru, IN

Key dates

• Filing date: Sep 1, 2016
• Grant date: Jan 28, 2020
• Expiry date: Sep 1, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to an improved process for the preparation of xylene linked cyclam compounds. More particularly the invention provides a process for preparation of high purity plerixafor which does not involve the use of expensive chemicals, hazardous reagents or tedious purification techniques. Invention also provides novel intermediate useful for preparation of desired compound in high purity.