Purine inhibitors of human phosphatidylinositol 3-kinase delta

US10544147B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Abdelghani Achab · Melrose, US
• Matthew Christopher · Brookline, US
• Francesc Xavier Fradera Llinas · Brookline, US
• Jason Katz · Leominster, US
• Joey L. Methot · Westwood, US
• Hua Zhou · Acton, US
• Shimin Xu · Beijing, CN
• Jianmin Fu · Beijing, CN
• Ning Fu · Beijing, CN
• Yabin Li · Hangzhou City, CN
• Xichao Wang · Beijing, CN

Key dates

• Filing date: Mar 24, 2017
• Grant date: Jan 28, 2020
• Expiry date: Mar 24, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The instant invention provides compounds of formula (I) which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.