Nanoparticle immunoconjugates

US10548989B2 · kind B2 · utility

Assignees

• Memorial Sloan Kettering Cancer Center · US
• Cornell University · IT
• The Curators of the University of Missouri · US

Inventors

• Michelle S. Bradbury · Andover, US
• Thomas P. Quinn · Sunnyvale, US
• Feng-Jing Chen · New York, US
• Barney Yoo · New York, US
• Jason S. Lewis · New York, US
• Ulrich Wiesner · Ithaca, US
• Kai Ma · Ithaca, US

Key dates

• Filing date: Apr 7, 2016
• Grant date: Feb 4, 2020
• Expiry date: Apr 7, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/622
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.