Methods and compositions for enhancing immune responses

US10561722B2 · kind B2 · utility

Assignees

• Bavarian Nordic A/S · DK
• Janssen Vaccines & Prevention B.V.
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Ariane Volkmann · Andechs, DE
• Robin Steigerwald · Munich, DE
• Ulrike Dirmeier · Starnberg, DE
• Benoit Christophe Stephan CALLENDRET · The Hague, NL
• Macaya Julie DOUOGUIH · Reston, US
• Lucy A. Ward · Silver Spring, US

Key dates

• Filing date: Sep 3, 2015
• Grant date: Feb 18, 2020
• Expiry date: Sep 3, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/14234
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods are described for generating an improved effective immune response against an immunogen in humans. The enhanced immune response, is obtained by using an MVA vector as a prime and an adenovirus vector as a boost and is characterized by a high level of antibody response specific to the immunogen, and an enhanced cellular immune response. The compositions and methods can be used to provide a protective immunity against a disease, such as an infection of one or more subtypes of Ebola and Marburg filoviruses, in humans.