Bridged piperidine derivatives

US10562903B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Bjoern Bartels · Schopfheim, DE
• Hasane Ratni · Habsheim, FR
• Karlheinz Baumann · Weil am Rhein, DE
• Guido Galley · Rheinfelden (Baden), DE
• Georg Jaeschke · Basel, CH
• Roland Jakob-Roetne · Inzlingen, DE
• Anja Limberg · Penzberg, DE
• Werner Neidhart · Hagenthal-le-Bas, FR
• Rosa Maria Rodriguez-Sarmiento · Basel, CH

Key dates

• Filing date: Jun 8, 2018
• Grant date: Feb 18, 2020
• Expiry date: Jun 8, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound of formula wherein The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.