Patent · US Active

DNA polymerases with increased 3′-mismatch discrimination

US10563182B2 · kind B2 · utility

1Cited by

0References

11Claims

0Family size

Assignee

Roche Molecular Systems, Inc. · US

Inventors

Fred Reichert · Oakland, US
Keith Bauer · Los Altos, US
Thomas W. Myers · Dublin, US

Key dates

Filing date	Nov 22, 2017
Grant date	Feb 18, 2020
Priority date	—
Expiry date	Dec 27, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y207/07007
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.