Pyrrolobenzodiazepines and conjugates thereof

US10576164B2 · kind B2 · utility

Assignees

• MedImmune Limited · US
• Genentech, Inc. · US

Inventors

• Philip Wilson Howard · London, GB
• John A. Flygare · Burlingame, US
• Thomas Pillow · South San Francisco, US
• BinQing Wei · Belmont, US

Key dates

• Filing date: Oct 17, 2017
• Grant date: Mar 3, 2020
• Expiry date: Jan 27, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Conjugate compounds of formula (A): wherein: where R36a and R36b are independently selected from H, F, C1-4 saturated alkyl, C2-3 alkenyl, which alkyl and alkenyl groups are optionally substituted by a group selected from C1-4 alkyl amido and C1-4 alkyl ester; or, when one of R36a and R36b is H, the other is selected from nitrile and a C1-4 alkyl ester;