Bispecific HER2 antibodies and methods of use

US10584178B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Rebecca CROASDALE-WOOD · Penzberg, DE
• Lydia Jasmin Hanisch · Schlieren, CH
• Guy Georges · Habach, DE
• Thomas Hofer · Zürich, CH
• Ralf Hosse · Baar, CH
• Christian Klein · Iffeldorf, DE
• Ekkehard Moessner · Kreuzlingen, CH
• Samuel Moser · Rotkreuz, CH
• Wolfgang Schaefer · Sankt Augustin, DE
• Juergen Michael Schanzer · Traunstein, DE
• Werner Scheuer · Penzberg, DE
• Claudio Sustmann · Munich, DE
• Pablo Umana · Wollerau, CH

Key dates

• Filing date: Jun 17, 2016
• Grant date: Mar 10, 2020
• Expiry date: Aug 14, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to bispecific HER2 antibodies, novel HER2 antibody variants, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.