Monovalent antigen binding proteins

US10611825B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Birgit Bossenmaier · Hanerau-Hademarschen, DE
• Hubert Kettenberger · Munich, DE
• Christian Klein · Iffeldorf, DE
• Klaus-Peter Kuenkele · Perchtoldsdorf, AT
• Joerg Thomas Regula · Munich, DE
• Wolfgang Schaefer · Sankt Augustin, DE
• Manfred Schwaiger · Bergen, DE
• Claudio Sustmann · Munich, DE

Key dates

• Filing date: Jun 12, 2017
• Grant date: Apr 7, 2020
• Expiry date: Jul 3, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to monovalent antigen binding proteins with a CH1-CL domain exchange, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.