Minimal saponin analogues, synthesis and use thereof

US10626137B2 · kind B2 · utility

Assignee

• Memorial Sloan Kettering Cancer Center · US

Inventors

• David Y. Gin · New York, US
• Eric CHEA · Great Neck, US
• Alberto Fernandez-Tejada · Kingston, US
• Derek Shieh Tan · New York, US
• Jason S. Lewis · New York, US
• Jeffrey GARDNER · New York, US
• NagaVaraKishore Pillarsetty · New York, US

Key dates

• Filing date: Jun 1, 2015
• Grant date: Apr 21, 2020
• Expiry date: Jul 25, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.