Stabilized single human CD4 domains and fusion proteins

US10647754B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Dimiter S. Dimitrov · Frederick, US
• Weizao Chen · Frederick, US
• Prabakaran Ponraj · Germantown, US

Key dates

• Filing date: Oct 16, 2017
• Grant date: May 12, 2020
• Expiry date: Oct 16, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a polypeptide comprising a single domain CD4, as well as a fusion protein comprising the single domain CD4 and one or more fusion partners. A nucleic acid encoding the polypeptide or fusion protein, as well as compositions or cells comprising the polypeptide, fusion protein, or nucleic acid also are provided.