Patent · US Active

Amino acid sequence presenting fusion polypeptide and its use

US10647765B2 · kind B2 · utility

0Cited by

2References

4Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Herbert Andres · Penzberg, DE
David Casagolda Vallribera · Barcelona, ES
Hartmut Duefel · Schlehdorf, DE
Michael Gerg · Munich, DE
Christian Scholz · Penzberg, DE
Michael Schraeml · Penzberg, DE

Key dates

Filing date	Mar 16, 2018
Grant date	May 12, 2020
Priority date	—
Expiry date	Apr 25, 2038

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/99
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Herein is reported a fusion polypeptide according to formula I NH2—S2—X1—S1—COOH (formula I) wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and — denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.