Multi-chain polypeptide-containing tri-specific binding molecules

US10647768B2 · kind B2 · utility

Assignee

• Macrogenics, Inc. · US

Inventors

• Leslie S. Johnson · Travilah, US
• Ling Huang · Bethesda, US
• Gurunadh Reddy Chichili · Germantown, US
• Kalpana Shah · Rockville, US
• Chia-Ying Kao Lam · Foster City, US
• Stephen James Burke · Rockville, US
• Liqin Liu · Germantown, US
• Paul A. Moore · North Potomac, US
• Ezio Bonvini · Potomac, US
• Bhaswati Barat · Los Angeles, US

Key dates

• Filing date: May 29, 2015
• Grant date: May 12, 2020
• Expiry date: May 29, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Binding Domains may be selected such that the Tri-Specific Binding Molecules are capable of binding to any three different epitopes. Such epitopes may be epitopes of the same antigen or epitopes of two or three different antigens. In a preferred embodiment, one of such epitopes will be capable of binding to CD3, the second of such epitopes will be capable of binding to CD8, and the third of such epitopes will be capable of binding to an epitope of a Disease-Associated Antigen. The invention also provides a novel ROR1-binding antibody, as well as derivatives thereof and uses for such compositions.