Inhibitors of histone deacetylase

US10662199B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• The General Hospital Corporation · US
• Massachusetts Institute of Technology · US

Inventors

• Edward Holson · Newton, US
• Florence Fevrier Wagner · Ashland, US
• Michel Weiwer · Cambridge, US
• Li-Huei Tsai · Cambridge, US
• Stephen J. Haggarty · Somerville, US
• Yan Zhang · Fort Washington, US

Key dates

• Filing date: Oct 17, 2017
• Grant date: May 26, 2020
• Expiry date: Oct 17, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/50
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.