Patent assignee · US · UNIVERSITY

The Broad Institute, Inc.

428Patents
428Active
428Granted
62Portfolio score

Filing activity: Nov 1, 2010 → Dec 6, 2024 · 2 expiring within 5 years

Most-cited patents

PatentTitleAreaCited byStatus
US8697359B1 CRISPR-Cas systems and methods for altering expression of gene products Chemistry; Metallurgy 1,050 Active
US8993233B2 Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains Chemistry; Metallurgy 490 Active
US8795965B2 CRISPR-Cas component systems, methods and compositions for sequence manipulation Physics 470 Active
US8871445B2 CRISPR-Cas component systems, methods and compositions for sequence manipulation Physics 448 Active
US8865406B2 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation Emerging Cross-Sectional Technologies 425 Active
US8906616B2 Engineering of systems, methods and optimized guide compositions for sequence manipulation Physics 422 Active
US8945839B2 CRISPR-Cas systems and methods for altering expression of gene products Chemistry; Metallurgy 416 Active
US8999641B2 Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains Chemistry; Metallurgy 407 Active
US8771945B1 CRISPR-Cas systems and methods for altering expression of gene products Chemistry; Metallurgy 404 Active
US8932814B2 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes Chemistry; Metallurgy 397 Active
US8889418B2 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation Emerging Cross-Sectional Technologies 391 Active
US8889356B2 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes Chemistry; Metallurgy 373 Active
US8895308B1 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation Emerging Cross-Sectional Technologies 365 Active
US9790490B2 CRISPR enzymes and systems Emerging Cross-Sectional Technologies 303 Active
US9822372B2 CRISPR-Cas component systems, methods and compositions for sequence manipulation Physics 152 Active
US9840713B2 CRISPR-Cas component systems, methods and compositions for sequence manipulation Physics 133 Active
US8614092B2 Nucleotide-specific recognition sequences for designer TAL effectors Chemistry; Metallurgy 79 Active
US8450107B1 Nucleotide-specific recognition sequences for designer TAL effectors Chemistry; Metallurgy 78 Active
US9834791B2 CRISPR-related methods and compositions with governing gRNAS Chemistry; Metallurgy 78 Active
US8507272B2 Nucleotide-specific recognition sequences for designer TAL effectors Chemistry; Metallurgy 72 Active
US10930367B2 Methods, models, systems, and apparatus for identifying target sequences for Cas enzymes or CRISPR-Cas systems for target sequences and conveying results thereof Chemistry; Metallurgy 64 Active
US8481309B2 Nucleotide-specific recognition sequences for designer TAL effectors Chemistry; Metallurgy 64 Active
US10266886B2 CRISPR effector system based diagnostics Emerging Cross-Sectional Technologies 51 Active
US11041173B2 Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications Physics 49 Active
US10577630B2 Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy Chemistry; Metallurgy 48 Active

Source: USPTO / EPO open patent data. Counts and citation impact are objective bibliographic measures.