Thymic stromal lymphopoietin receptor-specific chimeric antigen receptors and methods using same

US10676528B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Haiying Qin · Potomac, US
• Terry J. Fry · Denver, US

Key dates

• Filing date: Oct 30, 2014
• Grant date: Jun 9, 2020
• Expiry date: May 11, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain specific for TSLPR, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of a proliferative disorder, e.g., cancer, in a mammal and methods of treating or preventing a proliferative disorder, e.g., cancer, in a mammal are also disclosed.