Methods for pharmacologic treatment of stroke

US10695355B2 · kind B2 · utility

Assignees

• UNIVERSITY OF CONNECTICUT · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Bruce Liang · Avon, US
• Rajkumar Verma · New Haven, US
• Kenneth A. Jacobson · Silver Spring, US

Key dates

• Filing date: Mar 23, 2018
• Grant date: Jun 30, 2020
• Expiry date: Jun 21, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/5517
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are methods for the treatment of a human subject who has had a stroke by administering to the subject a pharmaceutical composition including an antagonist of the P2X4 receptor. The antagonist of the P2X4 receptor can be administered in the acute phase of stroke, optionally in combination with a thrombolytic therapeutic or a procedure on the subject involving a clot-removal device.