Process for preparing beta 3 agonists and intermediates

US10696681B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Feng Xu · Durham, US
• Zhuqing Liu · Edison, US
• Richard Desmond · Metuchen, US
• Jeonghan Park · Flanders, US
• Alexei Kalinin · Kingston, CA
• Birgit Kosjek · Westfield, US
• Hallena Strotman · Somerville, US
• Hongmei Li · Hackettstown, US
• Johannah Moncecchi · Waltham, US

Key dates

• Filing date: Mar 11, 2019
• Grant date: Jun 30, 2020
• Expiry date: Mar 11, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.