Chemical conjugates of Evans Blue derivatives and their use in the production of long-acting therapeutics

US10709790B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Xiaoyuan Chen · Acton, US
• Lixin Lang · North Potomac, US
• Gang Niu · Shanxi, CN

Key dates

• Filing date: Jun 21, 2016
• Grant date: Jul 14, 2020
• Expiry date: Jun 21, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C09B29/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to a compound of Formula I or Formula II or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt: Formula I Formula II The compounds of Formula I may be covalently bonded to a therapeutic compound or fragment thereof to provide a compound of Formula II and thereby extend the half-life of the therapeutic compound. The invention is also directed to pharmaceutical compositions of the disclosed compounds, as well as their use in the diagnosis or treatment of diseases.