Biosensor for electrical detection of a nucleotide sequence
US10712308B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 3, 2016 |
| Grant date | Jul 14, 2020 |
| Priority date | — |
| Expiry date | Jan 6, 2038 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01L23/53242
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates generally to the field of microelectronics, and more particularly to a structure and method of forming a biosensor having a nucleotide attracting surface formed to reduce false detection of nucleotides and enabling electrical detection of nucleotides. The biosensor may include an analyte-affinity layer on an upper surface of a substrate. A conductive layer may extend a length of the substrate below and in contact with the analyte-affinity layer. The conductive layer may be electrically connected to one or more transistors. The analyte-affinity layer may have dimensions tailored for a target analyte. A distance between a first analyte-affinity layer and a second analyte-affinity layer may range from approximately 50% of a length of a target analyte to approximately 300% of a length of a target analyte. The analyte-affinity layer may have an upper surface with a diameter ranging from approximately 3 nm to approximately 20 nm.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.