Bispecific molecules comprising an HIV-1 envelope targeting arm

US10717778B2 · kind B2 · utility

Assignees

• Duke University · US
• Macrogenics, Inc. · US
• The University of North Carolina at Chapel Hill · US

Inventors

• Barton F. Haynes · Durham, US
• Guido Ferrari · Durham, US
• Scott Koenig · Rockville, US
• Leslie S. Johnson · Travilah, US
• Chia-Ying Kao Lam · Foster City, US
• Julia A. Sung · Chapel Hill, US
• David M. Margolis · Chapel Hill, US
• Liqin Liu · Germantown, US
• Jeffrey Lee Nordstrom · Olney, US

Key dates

• Filing date: Sep 29, 2015
• Grant date: Jul 21, 2020
• Expiry date: Sep 29, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecules and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells wherein the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28, or CH44.