Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof

US10722591B2 · kind B2 · utility

Assignee

• DYNAVAX TECHNOLOGIES CORPORATION · US

Inventors

• Robert L. Coffman · Portola Valley, US
• Stewart Chipman · Reading, US
• Radwan Kiwan · Albany, US
• Samuel Zalipsky · Redwood City, US
• Gary S. Ott · Oakland, US

Key dates

• Filing date: Nov 13, 2018
• Grant date: Jul 28, 2020
• Expiry date: Nov 13, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to cleavable conjugates (for example, particle-based or antibody-based conjugates) of TLR7/8 agonists (for example, 1H-imidazo[4,5-c]quinoline derivatives) containing a conjugation linker, a cleavable linker, and a self-eliminating linker. The present disclosure also related to methods for preparation of the cleavable conjugates, uses thereof for stimulating an effective immune response, and uses thereof for the treatment of cancer.