Patent · US Active

Small molecule based conversion of somatic cells into neural crest cells

US10724000B2 · kind B2 · utility

2Cited by

0References

10Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Martin Graf · Richmond, US
Roberto Iacone · Basel, CH
Eva Christina Thoma · Basel, CH

Key dates

Filing date	Jan 22, 2016
Grant date	Jul 28, 2020
Priority date	—
Expiry date	Jan 22, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2506/1307
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This application relates to a method for differentiating somatic cells into multi-competent neural crest cells based on linked steps of chemically defined medium inductions. Neural crest cells are able to differentiate into numerous cell types like Schwann cells, chondrocytes, smooth muscle cells or adipocytes.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.