Hindered disulfide drug conjugates
US10729738B2 · kind B2 · utility
0Cited by
13References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 14, 2016 |
| Grant date | Aug 4, 2020 |
| Priority date | — |
| Expiry date | Nov 2, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D521/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates generally to disulfide drug conjugates wherein a linker comprising a sulfur-bearing carbon atom substituted with at least one hydrocarbyl or substituted hydrocarbyl is conjugated by a disulfide bond to a cysteine sulfur atom of a targeting carrier, and wherein the linker is further conjugated to a drug moiety. The invention further relates to activated linker-drug conjugates suitable for conjugation to a targeting carrier by a disulfide bond. The invention further relates to methods for preparing hindered disulfide drug conjugates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.