Benzo[b]thiophene compounds as STING agonists

US10730849B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Michael D. Altman · Cambridge, US
• Brandon D. Cash · Framingham, US
• Wonsuk Chang · Princeton, US
• Jared N. Cumming · Garwood, US
• Andrew M. Haidle · Cambridge, US
• Timothy J. Henderson · Natick, US
• James P. Jewell · Jersey City, US
• Matthew A. Larsen · Dedham, US
• Rui Liang · Plainsboro, US
• Jongwon Lim · Lexington, US
• Min Lu · San Diego, US
• Ryan D. Otte · Natick, US
• Tony Siu · Brookline, US
• Benjamin Wesley Trotter · Medfield, US
• Sriram Tyagarajan · Edison, US

Key dates

• Filing date: Jul 16, 2019
• Grant date: Aug 4, 2020
• Expiry date: Jul 16, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of general formula (Ia), compounds of general formula (Ia′), compounds of general formula (Ib), compounds of general formula (Ib′), compounds of general formula (I), compounds of general formula (I′), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.