Dual specific anti-CD22-anti-CD19 chimeric antigen receptors

US10738116B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Terry J. Fry · Denver, US
• Crystal L. Mackall · Silver Spring, US
• Rimas J. Orentas · Seattle, US
• Waleed M. Haso · Santa Monica, US
• Haiying Qin · Potomac, US

Key dates

• Filing date: Mar 18, 2016
• Grant date: Aug 11, 2020
• Expiry date: Apr 1, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/03
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention provides dual specific chimeric antigen receptors (CARs) having antigenic specificity for CD19 and CD22. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.