Dopamine D2 receptor ligands

US10752588B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US

Inventors

• Edward Holson · Newton, US
• Florence Fevrier · Ashland, US
• Michel Weiwer · Cambridge, US
• Edward Scolnick · Wayland, US
• Michelle Palmer · Harvard, US
• Michael C. Lewis · Dedham, US
• Jennifer Q. Pan · Acton, US
• Yan Zhang · Fort Washington, US
• Qihong Xu · Newton, US

Key dates

• Filing date: Dec 18, 2015
• Grant date: Aug 25, 2020
• Expiry date: Dec 18, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity.