Myelin oligodendrocyte glycoprotein, myelin basic protein, and proteolipid protein compositions and methods of use

US10759838B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Michael J. Lenardo · Potomac, US
• Jian Li · Tempe, US
• Lixin Zheng · Kirkland, US
• Jae-Woon Lee · Seojong-myeon, KR
• Wei-Shu Lu · Taipei, TW

Key dates

• Filing date: Mar 9, 2016
• Grant date: Sep 1, 2020
• Expiry date: Mar 9, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/50
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a protein comprising no more than three human autoantigenic proteins, wherein a first human autoantigenic protein comprises a truncated myelin oligodendrocyte glycoprotein (MOG) amino acid sequence, a second human autoantigenic protein comprises a myelin basic protein (MBP) amino acid sequence, and a third human autoantigenic protein comprises a truncated proteolipid protein (PLP) amino acid sequence. Also disclosed are related nucleic acids, pharmaceutical compositions, methods of treating a demyelinating disease, and methods of producing the proteins.