Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors

US10793538B2 · kind B2 · utility

Assignee

• The Broad Institute, Inc. · US

Inventors

• Edward Holson · Newton, US
• Fanny Lazzaro · Cambridge, US
• David Olson · Davis, US
• Florence Fevrier Wagner · Ashland, US
• Michel Weiwer · Cambridge, US

Key dates

• Filing date: Jan 24, 2018
• Grant date: Oct 6, 2020
• Expiry date: Jan 24, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of formula (I): or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein W, X, n, s, t, and Ra are as described herein. The present invention relates generally to selective inhibitors of histone deacetylase and to methods of making and using them.