[18F]-labelled lactate derivative as pet radiotracer

US10799470B2 · kind B2 · utility

Assignee

• GRANDIS · US

Inventors

• Pierre Sonveaux · Ottignies-Louvain-la-Neuve, BE
• Daniel Labar · Grand-Leez, BE
• Vincent Van Hée · Braine-l'Alleud, BE
• Gwenaël Dehon · Seneffe, BE
• Raphaël FRÉDÉRICK · Godinne, BE

Key dates

• Filing date: Sep 8, 2017
• Grant date: Oct 13, 2020
• Expiry date: Sep 8, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C59/115
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A positron emission tomography (PET) radiotracer for imaging lactate uptake, wherein the tracer is a [18F]-labelled lactate derivative which is [18F]-3-fluoro-2-hydroxypropionic acid: Also, a process for the radiosynthesis of the [18F]-labelled lactate derivative. Further, the use of the [18F]-labelled lactate derivative for imaging lactate uptake in living cells, especially in humans.