Expression vector delivery system and use thereof for inducing an immune response

US10799580B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• The Chancellor, Masters and Scholars of the University of Oxford · GB

Inventors

• Robert Seder · Chevy Chase Section Five, US
• Geoffrey Lynn · Baltimore, US
• Leonard Seymour · Birmingham, GB

Key dates

• Filing date: Sep 9, 2016
• Grant date: Oct 13, 2020
• Expiry date: Sep 9, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/6093
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.