Switchable non-scFv chimeric receptors, switches, and methods of use thereof to treat cancer
US10800828B2 · kind B2 · utility
2Cited by
29References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 28, 2016 |
| Grant date | Oct 13, 2020 |
| Priority date | — |
| Expiry date | Mar 28, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/27003
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are switchable chimeric receptors, switchable chimeric receptor effector cells and chimeric receptor effector cell switches. The switchable chimeric receptor-ECs are generally T cells. The chimeric receptors have non-antibody extracellular domains that recognize a chimeric receptor binding partner on the chimeric receptor-EC switch or target cell. The chimeric receptor-ECs and switches may be used for the treatment of a disease or condition in a subject in need thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.