Patent · US Active

Desacetoxytubulysin H and analogs thereof

US10808007B2 · kind B2 · utility

1Cited by

2References

18Claims

0Family size

Assignee

William Marsh Rice University · US

Inventors

Kyriacos C. Nicolaou · Philadelphia, US
Dionisios Vourloumis · San Diego, US
Jun Yin · Sichuan, CN
Rohan Diliprao Erande · Houston, US
Debashis Mandal · Fremont, US
Phillipp Klahn · Munster, DE

Key dates

Filing date	Feb 25, 2016
Grant date	Oct 20, 2020
Priority date	—
Expiry date	Feb 25, 2036

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein R1, R2, R3, R4, X1, X2, X3, and A1 are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.