Antiproliferation compounds and uses thereof

US10815225B2 · kind B2 · utility

Assignees

• Merck Patent GmbH · DE
• Vertex Pharmaceuticals Incorporated · US

Inventors

• Henry Yu · Wellesley, US
• Michael T. Clark · Linglestown, US
• Guy Bemis · Arlington, US
• Michael Boyd · Winchester, US
• Kishan Chandupatla · Boston, US
• Philip Collier · Arlington, US
• Hongbo Deng · Southborough, US
• Huijun Dong · Arlington, US
• Warren Dorsch · Boston, US
• Russell R. Hoover · Boston, US
• Mac Arthur Johnson, Jr. · Derry, US
• Shashank Kukarni · Waltham, US
• Marina Penney · Acton, US
• Steven Ronkin · Watertown, US
• Darin Takemoto · Belmont, US
• Qing Tang · Acton, US
• Nathan D. Waal · Cambridge, US
• Tiansheng Wang · Concord, US
• David J. Lauffer · Saline, US
• Pan Li · Lexington, US

Key dates

• Filing date: Apr 23, 2019
• Grant date: Oct 27, 2020
• Expiry date: Apr 23, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/113
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula I′, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).