T cell balance gene expression, compositions of matters and methods of use thereof

US10822587B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US
• President and Fellows of Harvard College · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Aviv Regev · Cambridge, US
• Vijay K. Kuchroo · Newton, US
• Hongkun Park · Lexington, US
• Nir Yosef · Richmond, US
• Alexander K. Shalek · Cambridge, US
• Jellert Gaublomme · Cambridge, US
• Nicole C. Joller · Brookline, US
• Chuan-Yin Wu · Newbury Park, US
• Ana Carrizosa Anderson · Boston, US

Key dates

• Filing date: Aug 27, 2015
• Grant date: Nov 3, 2020
• Expiry date: May 7, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.