Pyridyl-triazabicycles

US10829500B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Bjoern Bartels · Schopfheim, DE
• Cosimo Dolente · Allschwil, CH
• Wolfgang Guba · Memmingen, DE
• Wolfgang Haap · Bad Kötzting, DE
• Andreas Kuglstatter · Soest, DE
• Ulrike Obst Sander · Sursee, CH
• Jens-Uwe Peters · Weil am Rhein, DE
• Mark Rogers-Evans · Bottmingen, CH
• Thomas Woltering · Freiburg (Elbe), DE
• Christian Schnider · Basel, CH
• Roger Wermuth · Sissach, CH

Key dates

• Filing date: Jul 31, 2019
• Grant date: Nov 10, 2020
• Expiry date: Jul 31, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.