Method of sensitizing cancer cells to the cytotoxic effects of apoptosis inducing ligands in cancer treatment

US10849912B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• Arizona Board of Regents on Behalf of the University of Arizona · US

Inventors

• Thomas Joseph Sayers · Boonsboro, US
• Alan David Brooks · Frederick, US
• Curtis J. Henrich · Rockville, US
• Poonam Tewary · Frederick, US
• James B. McMahon · Frederick, US
• Leslie Gunatilaka · Tucson, US
• Ya-Ming Xu · Tucson, US
• Kithsiri Wijeratne · Tucson, US

Key dates

• Filing date: Feb 9, 2017
• Grant date: Dec 1, 2020
• Expiry date: Feb 9, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J71/001
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, which method comprises contacting the cancer cells with an apoptosis inducing ligand in conjunction with an effective amount of a compound of the formula: (I), wherein R1-R14 are as described herein. Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with the compound described herein and also contacting the cancer cells with an apoptosis inducing ligand, whereby apoptosis is induced in the cancer cells.