Patent · US Active

Pol6 polymerase variants

US10851353B2 · kind B2 · utility

0Cited by

7References

12Claims

0Family size

Assignees

Roche Sequencing Solutions, Inc. · US
Roche Molecular Systems, Inc. · US

Inventors

Evan Amato · Menlo Park, US
Cleoma Arnold · San Jose, US
Aruna Ayer · Santa Clara, US
Mara Boenitz-Dulat · Tutzing, DE
Barbara Eckert · Corona, US
Ilya Lederman · San Francisco, US
Colin Alexander McGaw · Santa Clara, US
Preethi Sarvabhowman · Santa Clara, US
Charles Wayan Schwab · San Ramon, US
Shawn Suko · El Sobrante, US
Eileen Thai · San Jose, US
Bigna Woersdoerfer · Munich, DE
David Daniel Wunderlich · Penzberg, DE

Key dates

Filing date	Mar 19, 2019
Grant date	Dec 1, 2020
Priority date	—
Expiry date	Mar 19, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2565/631
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present disclosure provides variant Pol6 polymerase polypeptides, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental Pol6 polypeptides from which they are derived.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.