Tricyclic Gyrase inhibitors

US10865216B2 · kind B2 · utility

Assignees

• Merck Sharp & Dohme LLC · US
• Lawrence Livermore National Security, LLC · US

Inventors

• Daniel Bensen · Carlsbad, US
• Allen Borchardt · San Diego, US
• Zhiyong Chen · San Diego, US
• John Finn · Mercerville, US
• Thanh To Lam · San Diego, US
• Suk Joong Lee · San Diego, US
• Xiaoming Li · Irvine, US
• Leslie W. TARI · San Diego, US
• Min Teng · Aliso Viejo, US
• Michael Trzoss · San Diego, US
• Junhu Zhang · San Diego, US
• Michael E. Jung · Los Angeles, US
• Felice C. Lightstone · Fremont, US
• Sergio E. Wong · Tracy, US
• Toan B. Nguyen · North Fair Oaks, US

Key dates

• Filing date: Sep 11, 2013
• Grant date: Dec 15, 2020
• Expiry date: Sep 11, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D515/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein.Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.