Azaindenoisoquinoline compounds and uses thereof

US10875860B2 · kind B2 · utility

Assignees

• Purdue Research Foundation · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Mark S. Cushman · West Lafayette, US
• Ping Wang · Huzhou City, CN
• Yves G. Pommier · Bethesda, US
• Mohamed S. A. Elsayed · West Lafayette, US

Key dates

• Filing date: Dec 19, 2017
• Grant date: Dec 29, 2020
• Expiry date: Dec 19, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Tyrosyl-DNA Phosphodiesterases 1 and 2 (Tdp1 and Tdp2) can repair damaged DNA resulting from topoisomerase inhibitors (e.g. Top1) and a variety of other DNA-damaging agents. 7-Azaindenoisoquinolines that are inhibitors of each of Top1, Tdp1 and Tdp2 are disclosed. Also described are methods for preparing azaindenoisoquinoline and methods for treating patients of a cancer using the disclosed azaindenoisoquinoline compounds or a pharmaceutical formulation thereof.