Bicyclic bis-heteroaryl derivatives as modulators of protein aggregation
US10889584B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Jan 23, 2018 |
| Grant date | Jan 12, 2021 |
| Priority date | — |
| Expiry date | Jan 23, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to certain bicyclic bis-heteroaryl compounds of Formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.