Small molecule dye for molecular imaging and photothermal therapy
US10894121B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 12, 2018 |
| Grant date | Jan 19, 2021 |
| Priority date | — |
| Expiry date | Mar 20, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/433
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a small molecule dye for use in imaging in the near-infrared window, namely between 1000 nm-1700 nm wavelength. The present dyes are also useful for photoacoustic imaging and photothermal therapy. The dyes have a structure of a D-A-D (donor-acceptor-donor) fluorescent compound core and side chains rendering the compounds water soluble and easily conjugated to hydrophilic polymers and/or targeting ligands. Further disclosed is compound, CH1055 that can be PEGylated, conjugated to a targeting ligand, or conjugated to taurine. Key steps utilized to assemble the core structure of the target included a cross-Suzuki coupling reaction, iron reduction and N-thionylaniline induced ring closure. Four carboxylic acid groups were introduced into the donor-acceptor-donor (D-A-D) type fluorescent compound to impart a certain aqueous solubility and to allow facile conjugation to targeting ligands.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.