Furoquinolinediones as inhibitors of TDP2

US10906914B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• SUN YAT-SEN UNIVERSITY · CN

Inventors

• Linkun An · 流花街道, CN
• Christophe Marchand · Gaithersburg, US
• Yves Pommier · Bethesda, US

Key dates

• Filing date: Jan 8, 2016
• Grant date: Feb 2, 2021
• Expiry date: Jan 8, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula I and the pharmaceutically acceptable salts thereof are disclosed Formula I. The variables X1, X2, and R1-4 are disclosed herein. The compounds are useful for treating cancer and related proliferative diseases. Pharmaceutical compositions containing compounds of Formula I and methods of treatment comprising administering compounds of Formula I are also disclosed.