Methods of treatments using chimeric antigen receptors targeting G-protein coupled receptor
US10906956B2 · kind B2 · utility
2Cited by
9References
20Claims
0Family size
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Key dates
| Filing date | Feb 21, 2020 |
| Grant date | Feb 2, 2021 |
| Priority date | — |
| Expiry date | Feb 21, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/03
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor (e.g., a G-protein coupled receptor family C group 5 member D (GPRC5D)), and immunoresponsive cells comprising such CARs. The presently disclosed CARs targeting a G-protein coupled receptor (e.g., GPRC5D) have enhanced immune-activating properties, including anti-tumor activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.