Substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors

US10927086B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Kun Liu · Edison, US
• Dane Clausen · Rahway, US
• Liangqin Guo · Edison, US
• Yongxin Han · Kirkland, CA
• Shuwen He · Fanwood, US
• Joseph A. Kozlowski · Princeton, US
• Derun Li · Dedham, US
• Qinglin Pu · Needham, US
• Wensheng Yu · Edison, US
• Hongjun Zhang · Waterloo, CA

Key dates

• Filing date: Feb 19, 2018
• Grant date: Feb 23, 2021
• Expiry date: Feb 19, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula I, or a pharmaceutically acceptable salt, solvate or hydrate thereof: (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.