Solid forms of an ASK1 inhibitor

US10946004B2 · kind B2 · utility

Assignee

• Gilead Sciences, Inc. · US

Inventors

• Mark Andres · West Lafayette, US
• Brenda J. Burke Chan · Foster City, US
• Ernest A. Carra · Foster City, US
• Anna Chiu · Burlingame, US
• Olga Viktorovna Lapina · Newark, US
• Stephen P. Lathrop · Lake Bluff, US
• Gregory Notte · Redwood City, US
• Valeriya Smolenskaya · West Lafayette, US
• Lok Him Yu · Sacramento, US

Key dates

• Filing date: Aug 2, 2019
• Grant date: Mar 16, 2021
• Expiry date: Aug 2, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.