Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
US10947222B2 · kind B2 · utility
1Cited by
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13Claims
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Key dates
| Filing date | Nov 13, 2017 |
| Grant date | Mar 16, 2021 |
| Priority date | — |
| Expiry date | Feb 2, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, nonalcoholic steatohepatitis (NASH), cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.